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Page 1
Tanshinone IIA inhibits HIF-1alpha and VEGF expression in breast cancer cells via mTOR/p70S6K/RPS6/4E-BP1 signaling pathway.
Li G, Shan C, Liu L, Zhou T, Zhou J, Hu X, Chen Y, Cui H, Gao N. Li G, et al. PLoS One. 2015 Feb 6;10(2):e0117440. doi: 10.1371/journal.pone.0117440. eCollection 2015. PLoS One. 2015. PMID: 25659153 Free PMC article.
In addition, we also found that T2A inhibited the angiogenesis and growth of human breast cancer xenografts in nude mice through suppression of HIF-1alpha and VEGF. Our study provides novel perspectives and potential targets for the treatment of human breast cancer. …
In addition, we also found that T2A inhibited the angiogenesis and growth of human breast cancer xenografts in nude mice through supp …
Calotropis Procera Induced Caspase-Dependent Apoptosis and Impaired Akt/mTOR Signaling in 4T1 Breast Cancer Cells.
Rabelo ACS, Miglino MA, Arbizu S, Carreira ACO, Filho AJC, Carneiro FJC, Layosa MAA, Noratto G. Rabelo ACS, et al. Anticancer Agents Med Chem. 2022;22(18):3136-3147. doi: 10.2174/1871520622666220608122154. Anticancer Agents Med Chem. 2022. PMID: 35676853
AIMS: Our goal was to investigate the anti-metastatic effects of phenolics extracted from C. procera (CphE) against 4T1 breast cancer cells and in BALB/c mice. METHODS: 4T1 cells were treated with CphE and quercetin (positive control) at concentrations that inhibited cell …
AIMS: Our goal was to investigate the anti-metastatic effects of phenolics extracted from C. procera (CphE) against 4T1 breast cancer …
MiR-129-5p Sensitizes the Response of Her-2 Positive Breast Cancer to Trastuzumab by Reducing Rps6.
Lu X, Ma J, Chu J, Shao Q, Zhang Y, Lu G, Li J, Huang X, Li W, Li Y, Ling Y, Zhao T. Lu X, et al. Cell Physiol Biochem. 2017;44(6):2346-2356. doi: 10.1159/000486122. Epub 2017 Dec 15. Cell Physiol Biochem. 2017. PMID: 29258115 Free article.
RESULTS: MiR-129-5p, which was downregulated and predicted to target rpS6 in trastuzumab-resistant breast cancer cells, enhanced the sensitivity of breast cancer cells to trastuzumab by reducing the expression of rpS6. ...CONCLUSIONS: MiR-129-5p sensit …
RESULTS: MiR-129-5p, which was downregulated and predicted to target rpS6 in trastuzumab-resistant breast cancer cells, enhanc …
Different Expression Levels of DLK2 Inhibit NOTCH Signaling and Inversely Modulate MDA-MB-231 Breast Cancer Tumor Growth In Vivo.
Naranjo AI, González-Gómez MJ, Baladrón V, Laborda J, Nueda ML. Naranjo AI, et al. Int J Mol Sci. 2022 Jan 29;23(3):1554. doi: 10.3390/ijms23031554. Int J Mol Sci. 2022. PMID: 35163478 Free PMC article.
NOTCH signaling is implicated in the development of breast cancer tumors. DLK2, a non-canonical inhibitor of NOTCH signaling, was previously shown to be involved in skin and breast cancer. ...In addition, DLK2 expression levels also affected some members of other ce …
NOTCH signaling is implicated in the development of breast cancer tumors. DLK2, a non-canonical inhibitor of NOTCH signaling, was pre …
Metformin: a new option in cancer treatment.
Belda-Iniesta C, Pernía O, Simó R. Belda-Iniesta C, et al. Clin Transl Oncol. 2011 Jun;13(6):363-7. doi: 10.1007/s12094-011-0669-y. Clin Transl Oncol. 2011. PMID: 21680296 Review.
Some preclinical data supports the inhibition of tumour cancer cell growth associated with mTOR inhibition and a decrease in phosphorylation of S6K, rpS6 and 4E-BP1. Here we have summarised some of the preclinical data and data of many clinical trials that are exploring th …
Some preclinical data supports the inhibition of tumour cancer cell growth associated with mTOR inhibition and a decrease in phosphorylation …
A time- and matrix-dependent TGFBR3-JUND-KRT5 regulatory circuit in single breast epithelial cells and basal-like premalignancies.
Wang CC, Bajikar SS, Jamal L, Atkins KA, Janes KA. Wang CC, et al. Nat Cell Biol. 2014 Apr;16(4):345-56. doi: 10.1038/ncb2930. Epub 2014 Mar 23. Nat Cell Biol. 2014. PMID: 24658685 Free PMC article.
Basal-like breast carcinoma is characterized by poor prognosis and high intratumour heterogeneity. ...The circuit depends on ECM engagement, as detachment causes a rewiring that is triggered by RPS6 dephosphorylation and maintained by juxtacrine tenascin C, which is …
Basal-like breast carcinoma is characterized by poor prognosis and high intratumour heterogeneity. ...The circuit depends on ECM enga …
Boolean ErbB network reconstructions and perturbation simulations reveal individual drug response in different breast cancer cell lines.
von der Heyde S, Bender C, Henjes F, Sonntag J, Korf U, Beißbarth T. von der Heyde S, et al. BMC Syst Biol. 2014 Jun 25;8:75. doi: 10.1186/1752-0509-8-75. BMC Syst Biol. 2014. PMID: 24970389 Free PMC article.
Drug impact on the AKT and ERK1/2 signalling axes is mirrored by effects on RB and RPS6, relating to phenotypic events like cell growth or proliferation. Therefore, we additionally analysed RB and RPS6 in the long-term networks. CONCLUSIONS: We derived protein inter …
Drug impact on the AKT and ERK1/2 signalling axes is mirrored by effects on RB and RPS6, relating to phenotypic events like cell grow …
MCF-7 breast cancer cells selected for tamoxifen resistance acquire new phenotypes differing in DNA content, phospho-HER2 and PAX2 expression, and rapamycin sensitivity.
Leung E, Kannan N, Krissansen GW, Findlay MP, Baguley BC. Leung E, et al. Cancer Biol Ther. 2010 May 1;9(9):717-24. doi: 10.4161/cbt.9.9.11432. Cancer Biol Ther. 2010. PMID: 20234184
Patients with estrogen receptor-positive (ER+) breast cancers are often treated with aromatase inhibitors or by antiestrogens such as tamoxifen to prevent disease recurrence. ...We have investigated this possibility in the case of the MCF-7 breast cancer cell line. …
Patients with estrogen receptor-positive (ER+) breast cancers are often treated with aromatase inhibitors or by antiestrogens such as …
Comparison of the effects of the PI3K/mTOR inhibitors NVP-BEZ235 and GSK2126458 on tamoxifen-resistant breast cancer cells.
Leung E, Kim JE, Rewcastle GW, Finlay GJ, Baguley BC. Leung E, et al. Cancer Biol Ther. 2011 Jun 1;11(11):938-46. doi: 10.4161/cbt.11.11.15527. Epub 2011 Jun 1. Cancer Biol Ther. 2011. PMID: 21464613 Free PMC article.
BACKGROUND: Treatment with anti-estrogens or aromatase inhibitors is commonly used for patients with estrogen receptor-positive (ER+) breast cancers; however resistant disease develops almost inevitably, requiring a choice of secondary therapy. ...The functional status of …
BACKGROUND: Treatment with anti-estrogens or aromatase inhibitors is commonly used for patients with estrogen receptor-positive (ER+) bre …
Bisphenol-A-induced inactivation of the p53 axis underlying deregulation of proliferation kinetics, and cell death in non-malignant human breast epithelial cells.
Dairkee SH, Luciani-Torres MG, Moore DH, Goodson WH 3rd. Dairkee SH, et al. Carcinogenesis. 2013 Mar;34(3):703-12. doi: 10.1093/carcin/bgs379. Epub 2012 Dec 7. Carcinogenesis. 2013. PMID: 23222814 Free PMC article.
Widespread distribution of bisphenol-A (BPA) complicates epidemiological studies of possible carcinogenic effects on the breast because there are few unexposed controls. To address this challenge, we previously developed non-cancerous human high-risk donor breast ep …
Widespread distribution of bisphenol-A (BPA) complicates epidemiological studies of possible carcinogenic effects on the breast becau …
22 results